Galantamine-d₃ (hydrobromide)

Galantamine-d₃ is intended for use as an internal standard for the quantification of galantamine by GC- or LC-MS. Galantamine is an alkaloid originally isolated from the bulbs and flowers of Galanthus that inhibits acetylcholinesterase (AChE; IC₅₀ = 636 nM).¹ It reverses growth inhibition and inhibits apoptosis, autophagic flux, and production of reactive oxygen species (ROS) induced by amyloid-β (Aβ) in neuronally differentiated PC12 cells.² Galantamine prevents soman toxicity and inhibits acetylcholinesterase in cynomolgus macaques (ED₅₀s = 590 and 362 μg/kg, respectively).³ It also decreases escape latency in the Morris water maze and the total hippocampal area of Aβ plaques in an APP/PS1 transgenic mouse model of Alzheimer's disease.⁴

WARNING This product is not for human or veterinary use.

1. Rook, Y., Schmidtke, K.U., Gaube, F., et al. Bivalent β-carbolines as potential multitarget anti-Alzheimer agents. J. Med. Chem. 53(9), 3611-3617 (2010).

2. Jiang, S., Zhao, Y., Zhang, T., et al. Galantamine inhibits β-amyloid-induced cytostatic autophagy in PC12 cells through decreasing ROS production. Cell Prolif. 51(3), e12427 (2018).

3. Hamilton, L.R., Schachter, S.C., and Myers, T.M. Time course, behavioral safety, and protective efficacy of centrally active reversible acetylcholinesterase inhibitors in cynomolgus macaques. Neurochem. Res. 42(7), 1962-1971 (2017).

4. Wu, Z., Zhao, L., Chen, X., et al. Galantamine attenuates amyloid-β deposition and astrocyte activation in APP/PS1 transgenic mice. Exp. Gerontol. 72, 244-250 (2015).